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KMID : 0984920150170010005
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Journal of Skin Barrier Research
2015 Volume.17 No. 1 p.5 ~ p.9
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Clinical Application of Proteomics in Skin Diseases
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Shin Jung-U
Lee Ju-Hee
Lee Kwang-Hoon
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Abstract
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The term "proteome" is rooted from the combination of two words; ``protein`` and ``ome``. It refers to the total proteins that are expressed by the entire genome. The proteomics, therefore, is the study of the total proteins. About 20,000 genes in human are transcribed into 100,000 RNAs, and these RNAs are translated into 1,000,000 proteins. Then the proteins undergo posttranslational modifications, such as phosphorylation and glycosylation, to gain their proper functions in our body. Therefore, the proteomics can reflect the functional aspects of the molecular biology better than the genomics and the transcriptomics, the study of DNAs and RNAs. The recent developments in the proteomics have led to the increased application of its concept not only in the fundamental molecular biology but also in the clinical medicine, including the identification of the biomarkers or investigation of pathogenesis in certain diseases. Our paper is a review for the topics that should be considered when performing the proteomics, and its application in studying the dermatologic diseases.
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KEYWORD
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Proteomics, Clinical, Dermatologic
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